Ferti male®

Packaging and dosage form:

90 F.C tablets with patient information brochure.

Ingredients and components:

Amount in each tablet:

Vitamin B6 6.25 mg

Vitamin B12 125 mcg

L-Arginine 250 mg

L-Carnitine 250 mg

Q10 25 mg

Vitamin E 25 IU

Zinc 3.75 mg

Selenium 12.5 mcg

Vitamin D3 250 IU

Indications:

-Helps improve sperm quality

-Helps improve men's reproductive health

How to use:

Take 4 tablets daily in two divided doses after lunch and dinner.

Pharmacological and Clinical effect:

- Vitamin B6

Vitamin B6 is essential for sperm production and maturation. One study found that vitamin B6 levels were significantly lower in the seminal plasma of men with asthenozoospermia (reduced sperm motility) compared to men with normal sperm motility.

Vitamin B6 helps neutralize free radicals and prevents damage to sperm DNA. Vitamin B6 deficiency may cause chemotoxicity and oxidative damage to sperm by increasing homocysteine levels.

- Vitamin B 12

Studies have shown that lower levels of vitamin B12 are associated with a higher likelihood of testosterone deficiency. Optimal levels of vitamin B12 increase the number, motility, and production of testosterone and reduce sperm damage. These factors increase fertility in men. Vitamin B12 has a positive effect on semen quality as it has been shown to increase sperm count and motility, and adequate levels of vitamin B12 help reduce DNA damage in sperm cells.

- L-Arginine

L-Arginine is an amino acid found naturally in red meat, poultry, fish, and dairy products. It is essential for making protein and is commonly used for blood circulation. L-Arginine is converted in the body into a chemical called nitric oxide. Nitric oxide causes blood vessels to open up to improve blood flow. L-Arginine also stimulates the release of growth hormone, insulin, and other substances in the body.

L-Arginine supplementation has been shown to improve sperm motility and increase sperm count. Studies in infertile men with normal sperm counts but reduced motility showed that daily oral L-Arginine supplementation significantly improved sperm motility without any side effects.

L-Carnitine:

L-Carnitine is a compound that functions to transport long-chain fatty acids from the cytoplasm into the mitochondria, where it is used to produce cellular energy. Most of the biosynthesis of carnitine occurs in the liver and kidneys. Meat and dairy products provide dietary carnitine. Carnitine is stored in skeletal and cardiac muscles, as well as in the liver and red blood cells. Carnitine is excreted in the urine and is usually reabsorbed by the kidneys.

Analyses showed that carnitines significantly improved total sperm motility, progressive sperm motility, and sperm morphology, but had no effect on sperm concentration. Therefore, the use of carnitine in male infertility appears to improve some sperm parameters.

L-carnitine has antioxidant properties that help reduce the level of reactive oxygen species (ROS), thereby protecting sperm from oxidative damage and improving overall sperm quality.

L-carnitine supplementation has been observed to regulate hormone levels including testosterone and luteinizing hormone (LH), which are crucial for spermatogenesis and overall male reproductive health.

- Q10:

Coenzyme Q10 is an essential cofactor for providing energy in chemical reactions in the body and is a lipophilic antioxidant component of the lipid membranes that surround all cells and various organelles.

Both the bioenergetic and antioxidant roles of Q10 suggest the possibility of involvement in sperm biochemistry and male infertility. Q10 can be determined in semen, where its concentration is correlated with sperm count and motility. Studies have shown that CoQ10 can enhance sperm motility. Research also suggests that CoQ10 supplementation can lead to significant improvements in sperm count and concentration. The antioxidant properties of CoQ10 help protect sperm from oxidative stress, leading to improved sperm quality.

- Vitamin E:

Vitamin E is a major fat-soluble component of the cellular antioxidant defense system and is obtained exclusively from the diet. It has several important roles in the body due to its antioxidant activity.

A potent antioxidant, vitamin E has been studied for its potential benefits on male fertility. Its primary role includes neutralizing free radicals and reducing oxidative stress, thereby protecting sperm and improving their quality.

- Zinc:

Zinc is an essential mineral that plays an important role in various body functions, including male reproductive health. It is crucial for sperm formation, DNA synthesis, and overall sperm quality.

Zinc has been shown to play an important role in the male reproductive system. Fertile groups have been reported to have higher zinc levels compared to infertile groups. Since zinc concentrations are very high in male reproductive organs such as the prostate, testicles, and sperm itself, its role in male reproduction is undeniable. Zinc is a trace element essential for normal spermatogenesis and steroidogenesis. Its deficiency is one of the factors contributing to decreased testicular function in infertile men.

- Selenium:

Selenium is an essential mineral that occurs naturally in many foods and is added to other foods. It is also available as a dietary supplement. Selenium is part of 25 very important selenoproteins. Selenoproteins play an important role in thyroid hormone metabolism, DNA synthesis, reproduction and protection against oxidative damage and infection.

Selenium is an essential mineral and plays an important role in male reproductive health, primarily due to its antioxidant properties and involvement in spermatogenesis.

The development of male reproductive tissue requires optimal levels of selenium in the testicles, and a small deviation, whether deficiency or excess, leads to abnormal development. Selenoproteins protect sperm from oxidative damage during the sperm maturation process. Thus, selenium and selenoproteins ensure sperm viability as well as protection against reactive oxygen species. Libido may also be increased with selenium. To maintain reproductive function in men and prevent infertility, selenium levels must be optimal.

- Vitamin D3

The active form of vitamin D has attracted attention for its potential role in male fertility. Research suggests that vitamin D receptors are present in male reproductive tissues, suggesting its involvement in spermatogenesis and overall reproductive function. The role of vitamin D in modulating testicular function, including hormone production and spermatogenesis, has been investigated in animals and humans.

Several studies have observed a positive association between vitamin D levels and sperm motility. One review found that vitamin D may enhance male fertility, particularly by improving sperm motility. In addition, intervention studies have confirmed that vitamin D supplementation positively affects sperm motility, particularly progressive motility.

Side Effects

It can cause general side effects including digestive upset such as nausea, bloating, or diarrhea, loss of appetite, heartburn, drowsiness, headache and dizziness, and skin rash. Taking this product with other products containing vitamin D, calcium, and vitamin E can cause serious side effects including vitamin D toxicity and increased risk of bleeding with high doses of vitamin E in the body.

Interaction:

This product can interact with blood thinners, antihypertensives, antidiabetics, sleeping pills and sedatives, antidepressants and anticonvulsants, some antibiotics including: cephalexin, ciprofloxacin, ofloxacin, levofloxacin, tetracycline, etc.

Precaution and Warning:

Consult your doctor before use if you have a history of heart, kidney, blood pressure, or any other medical condition.

Contraindication:

Avoid taking the product if you have a history of allergy to any of product's components.

Storage:

Store this product at a temperature below 25°C, away from light, moisture, and out of the reach of children.