Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders that plaques women today. One of the underlying factors associated with the development of PCOS is elevated inﬂammation. However, the application of available nutraceutical therapies remains relatively unknown and thus is the focus of the current study. In this manner, we evaluated the eﬀects of probiotic supplement on clinical and immunological parameters of PCOS. Our randomized-control trial, four strains of Lactobacillus for a probiotic group and the equivalent dosage with maltodextrin was used as the placebo. To further understand the impacts of immunological parameters towards inﬂammation in PCOS, we measured interleukin (IL) 6, 10, TNFα, hs-CRP and clinical manifestations before and after the trial. The probiotic supplementation resulted in a signiﬁcant increase in IL-10 levels compared with the placebo, after the intervention. However, in both groups, there was a signiﬁcant decrease in hs-CRP and IL-6 levels. Probiotic supplementation does not make any signiﬁcant changes in the TNFα levels. This study observed that Lactobacillus supplementation modulates inﬂammation in PCOS patients.
Keywords: Probiotics,Lactobacillus,Polycystic ovary syndrome, PCOS, Interleukins, hs-CRP
© All rights reserved the Web site